MaghrebDataLibMedV2, Main, Exploration, bibRecord, 000656

Evolutionary analysis of Mycobacterium bovis genotypes across Africa suggests co-evolution with livestock and humans

Identifieur interne : 000656 ( Main/Exploration ); précédent : 000655; suivant : 000657

Evolutionary analysis of Mycobacterium bovis genotypes across Africa suggests co-evolution with livestock and humans

Auteurs : Osvaldo Frederico Inlamea [Brésil] ; Pedro Soares [Portugal] ; Cassia Yumi Ikuta [Brésil] ; Marcos Bryan Heinemann [Brésil] ; Sara Juma Achá ; Adelina Machado ; José Soares Ferreira Neto [Brésil] ; Margarida Correia-Neves [Portugal] ; Teresa Rito [Portugal]

Source :

PLoS Neglected Tropical Diseases [ 1935-2727 ] ; 2020.

RBID : PMC:7077849

Descripteurs français

KwdFr :
- Afrique (épidémiologie), Analyse de regroupements (MeSH), Animaux (MeSH), Bovins (MeSH), Bétail (MeSH), Capra (MeSH), Génotype (MeSH), Humains (MeSH), Mycobacterium bovis (classification), Mycobacterium bovis (génétique), Mycobacterium bovis (isolement et purification), Ovis (MeSH), Phylogenèse (MeSH), Transmission de maladie infectieuse (MeSH), Tuberculose (microbiologie), Tuberculose (médecine vétérinaire), Tuberculose (épidémiologie), Variation génétique (MeSH), Épidémiologie moléculaire (MeSH).
MESH :
- génétique : Mycobacterium bovis.
- isolement et purification : Mycobacterium bovis.
- microbiologie : Tuberculose.
- médecine vétérinaire : Tuberculose.
- épidémiologie : Afrique, Mycobacterium bovis, Tuberculose.
- Analyse de regroupements, Animaux, Bovins, Bétail, Capra, Génotype, Humains, Ovis, Phylogenèse, Transmission de maladie infectieuse, Variation génétique, Épidémiologie moléculaire.

English descriptors

KwdEn :
- Africa (epidemiology), Animals (MeSH), Cattle (MeSH), Cluster Analysis (MeSH), Disease Transmission, Infectious (MeSH), Genetic Variation (MeSH), Genotype (MeSH), Goats (MeSH), Humans (MeSH), Livestock (MeSH), Molecular Epidemiology (MeSH), Mycobacterium bovis (classification), Mycobacterium bovis (genetics), Mycobacterium bovis (isolation & purification), Phylogeny (MeSH), Sheep (MeSH), Tuberculosis (epidemiology), Tuberculosis (microbiology), Tuberculosis (veterinary).
MESH :
- geographic , epidemiology : Africa.
- classification : Mycobacterium bovis.
- epidemiology : Tuberculosis.
- genetics : Mycobacterium bovis.
- isolation & purification : Mycobacterium bovis.
- microbiology : Tuberculosis.
- veterinary : Tuberculosis.
- Animals, Cattle, Cluster Analysis, Disease Transmission, Infectious, Genetic Variation, Genotype, Goats, Humans, Livestock, Molecular Epidemiology, Phylogeny, Sheep.

Abstract

Mycobacterium bovis is the pathogenic agent responsible for bovine tuberculosis (bTB), a zoonotic disease affecting mostly cattle, but also transmittable to humans and wildlife. Genetic studies on M. bovis allow to detect possible routes of bTB transmission and the identification of genetic reservoirs that may provide an essential framework for public health action.

We used a database with 1235 M. bovis genotypes collected from different regions in Africa with 45 new Mozambican samples. Our analyses, based on phylogeographic and population genetics’ approaches, allowed to identify two clear trends. First, the genetic diversity of M. bovis is geographically clustered across the continent, with the only incidences of long-distance sharing of genotypes, between South Africa and Algeria, likely due to recent European introductions. Second, there is a broad gradient of diversity from Northern to Southern Africa with a diversity focus on the proximity to the Near East, where M. bovis likely emerged with animal domestication in the last 10,000 years.

Diversity indices are higher in Eastern Africa, followed successively by Northern, Central, Southern and Western Africa, roughly correlating with the regional archaeological records of introduction of animal domesticates. Given this scenario M. bovis in Africa was probably established millennia ago following a concomitant spread with cattle, sheep and goat. Such scenario could translate into long-term locally adapted lineages across Africa.

This work describes a novel scenario for the spread of M. bovis in Africa using the available genetic data, opening the field to further studies using higher resolution genomic data.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077849

DOI: 10.1371/journal.pntd.0008081
PubMed: 32119671
PubMed Central: 7077849

Affiliations:

Le document en format XML

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 genotypes across Africa suggests co-evolution with livestock and humans</title>
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 genotypes across Africa suggests co-evolution with livestock and humans</title>
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<author><name sortKey="Machado, Adelina" sort="Machado, Adelina" uniqKey="Machado A" first="Adelina" last="Machado">Adelina Machado</name>
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<author><name sortKey="Ferreira Neto, Jose Soares" sort="Ferreira Neto, Jose Soares" uniqKey="Ferreira Neto J" first="José Soares" last="Ferreira Neto">José Soares Ferreira Neto</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Africa (epidemiology)</term>
<term>Animals (MeSH)</term>
<term>Cattle (MeSH)</term>
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</keywords>
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<term>Mycobacterium bovis</term>
<term>Tuberculose</term>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><p><italic>Mycobacterium bovis</italic>
 is the pathogenic agent responsible for bovine tuberculosis (bTB), a zoonotic disease affecting mostly cattle, but also transmittable to humans and wildlife. Genetic studies on <italic>M</italic>
. <italic>bovis</italic>
 allow to detect possible routes of bTB transmission and the identification of genetic reservoirs that may provide an essential framework for public health action.</p>
<p>We used a database with 1235 <italic>M</italic>
. <italic>bovis</italic>
 genotypes collected from different regions in Africa with 45 new Mozambican samples. Our analyses, based on phylogeographic and population genetics’ approaches, allowed to identify two clear trends. First, the genetic diversity of <italic>M</italic>
. <italic>bovis</italic>
 is geographically clustered across the continent, with the only incidences of long-distance sharing of genotypes, between South Africa and Algeria, likely due to recent European introductions. Second, there is a broad gradient of diversity from Northern to Southern Africa with a diversity focus on the proximity to the Near East, where M. bovis likely emerged with animal domestication in the last 10,000 years.</p>
<p>Diversity indices are higher in Eastern Africa, followed successively by Northern, Central, Southern and Western Africa, roughly correlating with the regional archaeological records of introduction of animal domesticates. Given this scenario <italic>M</italic>
. <italic>bovis</italic>
 in Africa was probably established millennia ago following a concomitant spread with cattle, sheep and goat. Such scenario could translate into long-term locally adapted lineages across Africa.</p>
<p>This work describes a novel scenario for the spread of <italic>M</italic>
. <italic>bovis</italic>
 in Africa using the available genetic data, opening the field to further studies using higher resolution genomic data.</p>
</div>
</front>
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<author><name sortKey="Silva, M" uniqKey="Silva M">M Silva</name>
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<author><name sortKey="Conde Sousa, E" uniqKey="Conde Sousa E">E Conde-Sousa</name>
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<author><name sortKey="Pereira, L" uniqKey="Pereira L">L Pereira</name>
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<author><name sortKey="Pereira, L" uniqKey="Pereira L">L Pereira</name>
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<author><name sortKey="Richards, Mb" uniqKey="Richards M">MB Richards</name>
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<author><name sortKey="Jones, Sc" uniqKey="Jones S">SC Jones</name>
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<author><name sortKey="Novelletto, A" uniqKey="Novelletto A">A Novelletto</name>
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<author><name sortKey="Rodriguez, Jn" uniqKey="Rodriguez J">JN Rodríguez</name>
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<name sortKey="Heinemann, Marcos Bryan" sort="Heinemann, Marcos Bryan" uniqKey="Heinemann M" first="Marcos Bryan" last="Heinemann">Marcos Bryan Heinemann</name>
<name sortKey="Ikuta, Cassia Yumi" sort="Ikuta, Cassia Yumi" uniqKey="Ikuta C" first="Cassia Yumi" last="Ikuta">Cassia Yumi Ikuta</name>
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<name sortKey="Correia Neves, Margarida" sort="Correia Neves, Margarida" uniqKey="Correia Neves M" first="Margarida" last="Correia-Neves">Margarida Correia-Neves</name>
<name sortKey="Rito, Teresa" sort="Rito, Teresa" uniqKey="Rito T" first="Teresa" last="Rito">Teresa Rito</name>
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Evolutionary analysis of Mycobacterium bovis genotypes across Africa suggests co-evolution with livestock and humans

Evolutionary analysis of Mycobacterium bovis genotypes across Africa suggests co-evolution with livestock and humans

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